Correlação entre a densidade microvascular sanguínea e linfática e a proliferação celular no carcinoma epidermóide de assoalho bucal e língua
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Data
2010-07-28
Autores
Bertini, Fernanda [UNESP]
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Editor
Universidade Estadual Paulista (Unesp)
Resumo
O carcinoma epidermóide (CE) representa 95% das neoplasias malignas bucais, sendo língua e assoalho as localizações intra-orais mais comuns. A angiogênese e a linfangiogênese estão relacionadas com desenvolvimento, disseminação e agressividade dos tumores. O objetivo deste estudo foi avaliar a relação entre as características histológicas, densidade microvascular sanguínea (MDV) e linfática (MDL) e proliferação celular no carcinoma epidermóide intra-oral (CEI). Sessenta casos de CEI, sendo 30 de assoalho bucal e 30 de língua, foram analisados e comparados quanto à gradação histológica de malignidade, a expressão do VEGF (fator de crescimento vascular endotelial) VEGF-C (fator de crescimento vascular endotelial - C) e sua correlação com a MDV e MDL. Verificou-se predomínio do gênero masculino em ambas as localizações, assim como da raça leucoderma. Quanto à gradação de malignidade, 73,3% dos casos de carcinoma epidermóide de língua e 96,67% dos casos de assoalho foram considerados muito agressivos. Foi notado um índice de proliferação celular médio maior nos casos de assoalho, entretanto, a diferença com relação à língua não foi estatisticamente significante. A maioria dos carcinomas avaliados teve ausência de marcação para VEGF(63,33% em língua e 70% em assoalho) e marcação positiva para VEGF-C (73,33% em língua e 79,31% em assoalho). A MDL foi maior nos casos de língua, com diferença significativa entre as regiões. Verificou-se que altos valores de MDV ocorrem nos casos com maior proliferação celular, o mesmo não acontecendo com a MDL. Não houve relação dos fatores de crescimento VEGF e VEGF-C com a MDV e MDL respectivamente. Assim pode-se concluir que: a gradação histológica de malignidade é maior nos casos de assoalho do que nos de língua; o índice de proliferação celular é semelhante nas duas regiões; a maioria...
Squamous cell carcinoma (SCC) represents 95% of the oral malignant neoplasias, being the tongue and the floor of the mouth the most common intraoral regions. The angiogenesis is essential to various pathological processes such as the development and dissemination of tumors as well as its agressivity. On the other hand, the lymphangiogenesis would be important in the development of tumor metastasis. The objective of this study is to evaluate the relation among histological characteristics, lymphatic and blood microvascular density and cell proliferation in intraoral squamous cell carcinoma (OSCC). Sixty cases of intraoral squamous cell carcinoma (OSCC) from the archives of the FOSJC – UNESP Pathology Laboratory, being 30 of floor of the mouth and 30 of tongue, will be analysed in relation to its histological gradation of malignancy. There was a predominance of males in both regions as well as the caucasian race. As for the grading of malignancy, 73.3% of cases of squamous cell carcinoma of tongue and 96.67% of cases of floor were very aggressive. It was noted a mean cell proliferation index increased in cases of floor, however, the difference an compared to the tongue was not statistically significant. Most carcinomas evaluated had no markings for VEGF (63.33% in language and 70% in floor) and positive staining for VEGF-C (73.33% and 79.31% and tongue on the floor). The LDV was greater in cases of tongue, with significant differences between regions. It was found that high values occur in cases of MVD with increased cell proliferation. There was no relation of the growth factors VEGF and VEGF-C with MDV and LDV, respectively... (Complete abstract click electronic access below)
Squamous cell carcinoma (SCC) represents 95% of the oral malignant neoplasias, being the tongue and the floor of the mouth the most common intraoral regions. The angiogenesis is essential to various pathological processes such as the development and dissemination of tumors as well as its agressivity. On the other hand, the lymphangiogenesis would be important in the development of tumor metastasis. The objective of this study is to evaluate the relation among histological characteristics, lymphatic and blood microvascular density and cell proliferation in intraoral squamous cell carcinoma (OSCC). Sixty cases of intraoral squamous cell carcinoma (OSCC) from the archives of the FOSJC – UNESP Pathology Laboratory, being 30 of floor of the mouth and 30 of tongue, will be analysed in relation to its histological gradation of malignancy. There was a predominance of males in both regions as well as the caucasian race. As for the grading of malignancy, 73.3% of cases of squamous cell carcinoma of tongue and 96.67% of cases of floor were very aggressive. It was noted a mean cell proliferation index increased in cases of floor, however, the difference an compared to the tongue was not statistically significant. Most carcinomas evaluated had no markings for VEGF (63.33% in language and 70% in floor) and positive staining for VEGF-C (73.33% and 79.31% and tongue on the floor). The LDV was greater in cases of tongue, with significant differences between regions. It was found that high values occur in cases of MVD with increased cell proliferation. There was no relation of the growth factors VEGF and VEGF-C with MDV and LDV, respectively... (Complete abstract click electronic access below)
Descrição
Palavras-chave
Carcinoma de celulas escamosas, Angiogênese, Vasos linfáticos, Imunoistoquímica
Como citar
BERTINI, Fernanda. Correlação entre a densidade microvascular sanguínea e linfática e a proliferação celular no carcinoma epidermóide de assoalho bucal e língua. 2010. 121 f. Tese (doutorado) – Universidade Estadual Paulista, Faculdade de Odontologia de São Jose dos Campos, 2010.