Modelo in situ de remineralização para determinar dose-resposta com dentifrícios de baixa concentração de fluoreto utilizando esmalte bovino
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Data
2009-02-10
Autores
Oliveira, Rebeca Afonso Devides [UNESP]
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Editor
Universidade Estadual Paulista (Unesp)
Resumo
Estudos realizados em diferentes países apontam o uso de dentifrícios fluoretados como o principal responsável pelo declínio na prevalência da cárie bem como pelo aumento na incidência da fluorose dentária. Um dos recursos para a promoção da saúde bucal e reparo das lesões cariosas, sem causar danos aos indivíduos, seria a diminuição da concentração de fluoreto no dentifrício mantendo a efetividade anticariogênica comparável a de um dentifrício padrão de mercado (1100 mg F/g) em situações de baixa ou alta atividade de cárie. O objetivo do presente estudo foi avaliar um modelo in situ de remineralização para determinar dose-resposta com dentifrícios de baixa concentração de fluoreto. O estudo foi duplo-cego linear, divido em 8 oito períodos experimentais com intervalos de 7 dias. Participaram da pesquisa 10 voluntários que utilizaram dispositivos palatinos contendo blocos de esmalte bovino desmineralizados. Foram estabelecidos dois regimes experimentais de 3 e 7 dias e 4 tratamentos com dentifrícios: placebo, 275, 550 e 1100 μg F/g. Foi realizada a análise da profundidade da desmineralização e decorridos os tempos experimentais realizaram-se as análises: de dureza (Knoop) de superfície e em secção longitudinal e da concentração de fluoreto presente no esmalte (μg F/mm3). Os dados apresentaram-se homogêneos e foram submetidos à análise de variância (p<0,05). A desmineralização apresentou uma profundidade média de 47,7 μm com característica de lesão de subsuperfície. As análises de dureza mostraram aumento na remineralização com o aumento da concentração de fluoreto nos dentifrícios com o regime experimental de 3 dias (p<0,05). O aumento no tempo de permanência na cavidade bucal e exposição aos dentifrícios fluoretados não aumentaram a concentração de fluoreto presente no esmalte para um mesmo dentifrício fluoretado (p>0,05)...
Studies developed in different countries indicate F dentifrices as the main reason for the decrease in caries prevalence as well as for the increase of dental fluorosis. One of the resources for oral health promotion and repair of carious lesions, with no damage to individuals, would be the reduction of F concentration in dentifrice with preservation of the anti-caries effect similar to a Gold Standard dentifrice (1100 mg F/g), during conditions of low or high caries activity. The aim of this study was to evaluate an in situ remineralization model for dose-response establishment using low fluoride concentration dentifrices. This randomized controlled double-blind study was performed according to the volunteers’ availability and had 8 experimental periods with 7-day intervals. The volunteers (n=10) wore palatal appliances containing demineralized bovine enamel blocks. Two experimental regimens (3 and 7 days) and dentifrices treatments (placebo, 275, 550 and 1100 μg F/g) were set. Demineralization depth using polarized light microscopy, surface and cross-sectioned hardness (Knoop) and F concentration in enamel (μg F/mm3) were determined. Data were homogeneous and submitted to analysis of variance (p<0.05). Demineralization areas presented a mean depth of 47.7 μm with traits of subsurface lesion. Hardness analysis showed a remineralization improvement as F concentration in dentifrices increased, for the 3-day experimental regimen (p<0.05). The augment of time in the oral cavity and of exposure to F dentifrices did not increase F concentration in enamel, considering similar F dentifrices (p>0.05). In addition, the dentifrice with 550 μg F/g (7 days) showed similar results of remineralization (p>0.05) when compared to dentifrices with 1100 μg F/g (3 and 7 days). It may be concluded that the in situ remineralization model showed the ability to verify dose-response with a 3-day... (Complete abstract click electronic access below)
Studies developed in different countries indicate F dentifrices as the main reason for the decrease in caries prevalence as well as for the increase of dental fluorosis. One of the resources for oral health promotion and repair of carious lesions, with no damage to individuals, would be the reduction of F concentration in dentifrice with preservation of the anti-caries effect similar to a Gold Standard dentifrice (1100 mg F/g), during conditions of low or high caries activity. The aim of this study was to evaluate an in situ remineralization model for dose-response establishment using low fluoride concentration dentifrices. This randomized controlled double-blind study was performed according to the volunteers’ availability and had 8 experimental periods with 7-day intervals. The volunteers (n=10) wore palatal appliances containing demineralized bovine enamel blocks. Two experimental regimens (3 and 7 days) and dentifrices treatments (placebo, 275, 550 and 1100 μg F/g) were set. Demineralization depth using polarized light microscopy, surface and cross-sectioned hardness (Knoop) and F concentration in enamel (μg F/mm3) were determined. Data were homogeneous and submitted to analysis of variance (p<0.05). Demineralization areas presented a mean depth of 47.7 μm with traits of subsurface lesion. Hardness analysis showed a remineralization improvement as F concentration in dentifrices increased, for the 3-day experimental regimen (p<0.05). The augment of time in the oral cavity and of exposure to F dentifrices did not increase F concentration in enamel, considering similar F dentifrices (p>0.05). In addition, the dentifrice with 550 μg F/g (7 days) showed similar results of remineralization (p>0.05) when compared to dentifrices with 1100 μg F/g (3 and 7 days). It may be concluded that the in situ remineralization model showed the ability to verify dose-response with a 3-day... (Complete abstract click electronic access below)
Descrição
Palavras-chave
Dentifrícios, Esmalte dentário, Fluor, Dureza, Remineralização dentária, Dentifrices, Dental enamel, Fluorine, Hardness, Tooth remineralization
Como citar
OLIVEIRA, Rebeca Afonso Devides. Modelo in situ de remineralização para determinar dose-resposta com dentifrícios de baixa concentração de fluoreto utilizando esmalte bovino. 2009. 59 f. Tese (doutorado) - Universidade Estadual Paulista, Faculdade de Odontologia de Araçatuba, 2009.