Estudo fitoquímico e atividades biológicas de Gomphrena elegans Mart. (Amaranthaceae)
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Data
2010-11-29
Autores
Mahmoud, Talal Suleiman [UNESP]
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Universidade Estadual Paulista (Unesp)
Resumo
O trabalho descreve a identificação, isolamento, elucidação estrutural de constituintes químicos de Gomphrena elegans, bem como a avaliação do perfil químico e a avaliação das potenciais atividades antineoplásica, alelopática, inseticida e antifúngica dos extratos dessa espécie provenientes de coleta realizada em março de 2007. As extrações das substâncias orgânicas foram feitas por sonicação durante 120 minutos e o sistema de solvente mais favorável foi hexano, clorofórmio, metanol e água. Os estudos fitoquímicos dos extratos das folhas, caule aéreo, caule submerso e raiz adventícia resultaram na identificação de 54 substâncias naturais pertencentes a classes distintas e o sal KNO3. A cromatografia CG-EM dos extratos hexânicos permitiu identificar 37 substâncias sendo: 14 alcanos (pentadecano, hexadecano, heptadecano, octadecano, nonadecano, 3-etil-5-(2- etilbutil)-octadecano, eicosano, docosano, tricosano, tetracosano, pentacosano, hexacosano, heptacosano e nonacosano); 7 alcenos (1-hexadeceno, 1-octadeceno, 3-eicoseno, 8-metil-1-deceno, 9-eicoseno, docoseno e 1-hexacoseno); 8 ésteres (palmitato de metila, palmitato de etila, linoleato de metila, linolenato de metila, 6- octadecenoato de metila, linoleolato de etila, linolenato de etila e 9-octadecenoato de etila); 1 aromático (diisobutil ftalato); 4 terpenos (dihidroactinidiolide, 7,11,15-trimetil- 3-metileno-hexadec-1-eno, laurenan-2-ona e esqualeno); 1 álcool (1-hexadecanol) e 2 cetona (6,10,14-trimetil-2-pentadecanona e 7,9-di-ter-butil-oxaspiro[4.5]deca-6,9- dien-2,8-diona). Os extratos clorofórmicos, metanólico e aquoso possibilitaram o isolamento de 20 substâncias sendo: 3 esteróides (b- sitostenona, b-sitosterol e 5α- estigmasta-7,22-dien-3b-ol); 2 terpenos (jatrofona e esqualeno); 6 ésteres...
This work describes the identification, isolation and the structure of Gomphrena elegans chemical components. It also assesses the chemical profile and potential anticancer, allelopathic, insecticidal and antifungal activity of extracts from this species, collected in March 2007. Organic compounds were extracted through sonication during 120 minutes. The most favorable solvent system was: hexane, chloroform, methanol and water. The extracts phytochemical studies (from leaves, aerial stem, submerse stem and adventitious root) identified 54 natural substances from different classes and the KNO3 salt. Gas chromatography copled with mass spectrometry (GC-MS) of hexane extracts identified 37 substances: 14 alkanes (pentadecane, hexadecane, heptadecane, octadecane nonadecane, 3-ethyl-5-(2- ethyl-butyl)-octadecane eicosane, docosane, tricosane, tetracosane, pentacosane, hexacosane, heptacosane and nonacosane); 7 alkenes (1-hexadecene, 1- octadecene, 3-eicosene, 8-methyl-1-decene, 9-eicosene, docosene and 1- hexacosene); 8 esters (methyl palmitate, ethyl palmitate, methyl linoleate, methyl linolenate, 6-octadecenoate methyl, ethyl linoleolate, ethyl linolenate and 9- octadecenoate ethyl); 1 aromatic (diisobutil phthalate); 4 terpenes (dihydroactinidiolide, 7,11,15-trimethyl-3-methylene-hexadeca-1-ene, laurenan-2-one and squalene); 1 alcohol (1-hexadecanol) and 2 ketones (6,10,14-trimethyl-2- pentadecanone and 7,9-di-tert-butyl-oxaspiro[4.5]deca-6,9-dien-2,8-dione). The chloroform, methanol and water extracts allowed the isolation of 20 substances... (Complete abstract click electronic access below)
This work describes the identification, isolation and the structure of Gomphrena elegans chemical components. It also assesses the chemical profile and potential anticancer, allelopathic, insecticidal and antifungal activity of extracts from this species, collected in March 2007. Organic compounds were extracted through sonication during 120 minutes. The most favorable solvent system was: hexane, chloroform, methanol and water. The extracts phytochemical studies (from leaves, aerial stem, submerse stem and adventitious root) identified 54 natural substances from different classes and the KNO3 salt. Gas chromatography copled with mass spectrometry (GC-MS) of hexane extracts identified 37 substances: 14 alkanes (pentadecane, hexadecane, heptadecane, octadecane nonadecane, 3-ethyl-5-(2- ethyl-butyl)-octadecane eicosane, docosane, tricosane, tetracosane, pentacosane, hexacosane, heptacosane and nonacosane); 7 alkenes (1-hexadecene, 1- octadecene, 3-eicosene, 8-methyl-1-decene, 9-eicosene, docosene and 1- hexacosene); 8 esters (methyl palmitate, ethyl palmitate, methyl linoleate, methyl linolenate, 6-octadecenoate methyl, ethyl linoleolate, ethyl linolenate and 9- octadecenoate ethyl); 1 aromatic (diisobutil phthalate); 4 terpenes (dihydroactinidiolide, 7,11,15-trimethyl-3-methylene-hexadeca-1-ene, laurenan-2-one and squalene); 1 alcohol (1-hexadecanol) and 2 ketones (6,10,14-trimethyl-2- pentadecanone and 7,9-di-tert-butyl-oxaspiro[4.5]deca-6,9-dien-2,8-dione). The chloroform, methanol and water extracts allowed the isolation of 20 substances... (Complete abstract click electronic access below)
Descrição
Palavras-chave
Quimica organica, Química vegetal, Phytochemistry
Como citar
MAHMOUD, Talal Suleiman. Estudo fitoquímico e atividades biológicas de Gomphrena elegans Mart. (Amaranthaceae). 2010. 246 f. Tese (doutorado) - Universidade Estadual Paulista, Instituto de Química de Araraquara, 2010.