Composition and Activity against Oral Pathogens of the Essential Oil of Melampodium divaricatum (Rich.) DC.
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Data
2014-03-01
Autores
Duarte Moreira, Raquel Regina [UNESP]
Martins, Gilmarcio Zimmermann [UNESP]
Botelho, Vinicius Teixeira [UNESP]
Santos, Luis Eduardo dos [UNESP]
Cavaleiro, Carlos
Salgueiro, Ligia
Andrade, Gessica
Gomes Martins, Carlos Henrique
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Editor
Wiley-Blackwell
Resumo
The chemical composition of the essential oil isolated from the aerial parts of Melampodium divaricatum (Rich.) DC. (Asteraceae) was characterized by GC-FID and GC/MS analyses. (E)-Caryophyllene (56.0%), germacrene D (12.7%), and bicyclogermacrene (9.2%) were identified as the major oil components. The antimicrobial activity of the oil against seven standard strains of oral pathogens from the American Type Culture Collection (ATCC) was evaluated by determining minimum inhibitory concentrations (MICs) using the microdilution method. MIC Values below 100 mu g/ml were obtained against Streptococcus sobrinus (90 mu g/ml), Lactobacillus casei (30 mu g/ml), S. mutans (20 mu g/ml), and S. mitis (18 mu g/ml). In contrast, the MIC values of the major oil compound (E)-caryophyllene were higher than 400 mu g/ml against all pathogens, suggesting that the activity of the oil might depend on minor oil components and/or on synergistic effects. The M. divaricatum essential oil is a promising agent to include in anticariogenic oral rinse formulations for the control of oral pathogens.
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(E)-Caryophyllene, Antimicrobial activity, Oral pathogens, Melampodium divaricatum, Essential oils
Como citar
Chemistry & Biodiversity. Weinheim: Wiley-v C H Verlag Gmbh, v. 11, n. 3, p. 438-444, 2014.