Caffeine Encapsulated in Small Unilamellar Liposomes: Characerization and In Vitro Release Profile

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Data

2013-10-03

Autores

Chorilli, Marlus [UNESP]
Calixto, Giovana [UNESP]
Rimerio, Thereana Cristina [UNESP]
Scarpa, Maria Virginia [UNESP]

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Editor

Taylor & Francis Inc

Resumo

Liposomes containing hydrogenated soy phosphatidylcholine (PCH), with or without cholesterol (CHOL) and caffeine (CAF), were prepared by sonication and characterized for encapsulation efficiency and mean diameter. Dynamic light scattering assay showed that the incorporation of CHOL decreased significantly the size of the liposomes and led to a more heterogeneous distribution of size raising the CAF encapsulation efficiency. The in vitro drug release studies showed that the encapsulation of the CAF in liposomes produced a reduction in the release rate and the inclusion of CHOL in the liposome formulation delayed still further the release of the CAF.

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Palavras-chave

Caffeine, hydrogenated soy phosphatidylcholine, in vitro drug release, liposomes

Como citar

Journal Of Dispersion Science And Technology. Philadelphia: Taylor & Francis Inc, v. 34, n. 10, p. 1465-1470, 2013.