Interactive effects of mechanical ventilation, inhaled nitric oxide and oxidative stress in acute lung injury
Nenhuma Miniatura disponível
Data
2014-01-01
Autores
Ronchi, Carlos Fernando [UNESP]
Ferreira, Ana Lúcia dos Anjos [UNESP]
Campos, Fabio Joly [UNESP]
Kurokawa, Cilmery Suemi [UNESP]
Carpi, Mario Ferreira [UNESP]
Moraes, Marcos Aurelio [UNESP]
Bonatto, Rossano César [UNESP]
Yeum, Kyung-Jin
Fioretto, José Roberto [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Elsevier B.V.
Resumo
To compare conventional mechanical ventilation (CMV) and high-frequency oscillatory ventilation (HFOV), with/without inhaled nitric oxide (iNO), for oxygenation, inflammation, antioxidant/oxidative stress status, and DNA damage in a model of acute lung injury (ALI). Lung injury was induced by tracheal infusion of warm saline. Rabbits were ventilated at F-IO2 1.0 and randomly assigned to one of five groups. Overall antioxidant defense/oxidative stress was assessed by total antioxidant performance assay, and DNA damage by comet assay. Ventilatory and hemodynamic parameters were recorded every 30 min for 4 h. ALI groups showed worse oxygenation than controls after lung injury. After 4 h of mechanical ventilation, HFOV groups presented significant improvements in oxygenation. HFOV with and without iNO, and CMV with iNO showed significantly increased antioxidant defense and reduced DNA damage than CMV without iNO. Inhaled nitric oxide did not beneficially affect HFOV in relation to antioxidant defense/oxidative stress and pulmonary DNA damage. Overall, lung injury was reduced using HFOV or CMV with iNO. (C) 2013 Elsevier B.V. All rights reserved.
Descrição
Palavras-chave
Conventional mechanical ventilation, DNA damage, High-frequency oscillatory ventilation, Inhaled nitric oxide, Pulmonary oxidative stress
Como citar
Respiratory Physiology & Neurobiology. Amsterdam: Elsevier Science Bv, v. 190, n. 1, p. 118-123, 2014.