Indoleamine 2,3-dioxygenase (IDO) Activity in Placental Compartments of Renal-Transplanted Pregnant Women
Nenhuma Miniatura disponível
Data
2014-07-01
Autores
Prado, Karen Matias do
Correa-Silva, Simone [UNESP]
Oliveira, Leandro Gustavo de [UNESP]
Saraiva Camara, Niels Olsen
Ono, Erica
Sandri, Silvana
Tourino, Melissa Cavalheiro
Campa, Ana
Lima, Larissa de Sa
Scavone, Cristoforo
Título da Revista
ISSN da Revista
Título de Volume
Editor
Wiley-Blackwell
Resumo
Problem Immunosuppressive drugs change gestational IDO activity at the maternal-fetal interface. Method of Study Analysis of placental IDO expression and activity, interferon gamma (IFN-), and IL-10 expression and NFkB activity in renal transplant recipient women under immunosuppressive treatment. Results We demonstrated a significant reduction in IDO activity (P=0.0275) and expression (P=0.026) and in NFkB activity (P=0.0176) in the villous region of renal transplanted mother. These findings did not correlate with the higher serum levels of kynurenine (P=0.002). In the decidual compartment, IDO was immunolocalized mainly on the extravillous cytotrophoblast but did not show significant differences among the experimental groups; kynurenine was significantly higher (P=0.036) and was inversely proportional to the decidual IFN- profile (P=0.0433). No change was seen in IL-10 levels. NFkB activity was significantly higher in decidual compartment correlating with the higher IDO activity and suggesting that in immunosuppressant pregnancy, IDO activity and expression remain regulated by NFkB. Conclusion The increased IDO activity in decidua may indicate an attempt to offset the low expression. These findings call attention to the relevance of IDO activity at the maternal interface in pregnant transplant recipients, likely modulated by immunosuppressive agents and associated with a high risk of associated gestational disorders.
Descrição
Palavras-chave
IDO, IFN-, Immunosuppressive drugs, Kynurenine, NF-B, Placenta
Como citar
American Journal Of Reproductive Immunology. Hoboken: Wiley-blackwell, v. 72, n. 1, p. 45-56, 2014.