Toxicity of dietary restriction of fat enriched diets on cardiac tissue
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Data
2002-12-01
Autores
Diniz, Y. S.
Faine, L. A.
Almeida, J. A.
Silva, MDP
Ribas, B. O.
Novelli, ELB
Título da Revista
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Editor
Elsevier B.V.
Resumo
The present study examines the effects of caloric restriction in cardiac tissue evaluation markers of oxidative stress. High-fat dietary restrictions can have a long-term impact on cardiac health. Dietary restriction of control diet increased myocardial superoxide dismutase (SOD) and catalase activities. Dietary restriction of fatty acid-enriched diets increased myocardial lipoperoxide concentrations, while SOD activity was decreased in cardiac tissue of rats with dietary restriction of fatty acid-enriched diets. Dietary restriction of unsaturated fatty acid-enriched diet induced the highest lipoperoxide concentration and the lowest myocardial SOD activity. Dietary restriction of unsaturated fatty acid decreased myocardial glycogen, and increased the lactate dehydrogenase/citrate synthase ratio. Dietary restriction of fatty acid-enriched diets were more deleterious to cardiac tissue than normal ad lib.-fed diet. In conclusion, the effects of caloric restriction on myocardial oxidative stress is dependent on which nutrient is restricted. Dietary restriction of fatty acid-enriched diets is deleterious relative to ad lib.-fed chow diet. (C) 2002 Elsevier, Science Ltd. All rights reserved.
Descrição
Palavras-chave
heart, dietary restriction, fatty acid, enzymes, oxidative stress
Como citar
Food and Chemical Toxicology. Oxford: Pergamon-Elsevier B.V., v. 40, n. 12, p. 1893-1899, 2002.