Downmodulation of peripheral MUG-specific immunity by pVAXhspe65 treatment during EAE does not reach the CNS
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Data
2014-03-15
Autores
Goncalves Zorzella-Pezavento, Sofia Fernanda [UNESP]
Chiuso-Minicucci, Fernanda [UNESP]
Donega Franca, Thais Graziela [UNESP]
Watanabe Ishikawa, Larissa Lumi [UNESP]
Rosa, Larissa Camargo da [UNESP]
Colavite, Priscila Maria [UNESP]
Marques, Camila
Valerio Ikoma, Maura Rosane
Silva, Celio Lopes
Sartori, Alexandrina [UNESP]
Título da Revista
ISSN da Revista
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Editor
Elsevier B.V.
Resumo
Most of the therapeutic strategies to control multiple sclerosis are directed to immune modulation and inflammation control. As heat shock proteins are able to induce immunoregulatory T cells, we investigated the therapeutic effect of a genetic vaccine containing the mycobacterial hsp65 gene on experimental autoimmune encephalomyelitis (EAE). Although pVAXhsp65 was immunogenic for mice with EAE and downmodulated specific cytokine induction by MOG, therapy was not able to decrease clinical severity nor to modify immunologic parameters in the CNS. These results indicate that hsp65, administered as a DNA vaccine, was not therapeutic for EAE. (C) 2014 Elsevier B.V. All rights reserved.
Descrição
Palavras-chave
Experimental autoimmune encephalomyelitis hsp65, DNA vaccine, CD4+CD25+Foxp3+T cells
Como citar
Journal Of Neuroimmunology. Amsterdam: Elsevier Science Bv, v. 268, n. 1-2, p. 35-42, 2014.