Polymeric Systems as Nanodevices for siRNA Delivery
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Data
2013-10-01
Autores
Tiera, Marcio J. [UNESP]
Shi, Qin
Goncalves Barbosa, Hellen Franciane [UNESP]
Fernandes, Julio C.
Título da Revista
ISSN da Revista
Título de Volume
Editor
Bentham Science Publ Ltd
Resumo
The delivery of small interfering RNAs (siRNAs) is a promising approach to silencing gene expression aimed at treating infections, cancer, neurodegenerative diseases and various other disorders. Recent progress in this area has been achieved with nanodevices possessing multiple properties and assembled with new, biodegradable, synthetic polymers and polysaccharides. Different synthetic routes and multiple strategies, such as multilayer systems and stimuli-responsive polymers, have been developed to attain high efficiencies. This review covers the most important, promising and successful approaches to improve siRNA delivery. It is a concise report on multiple strategies employed, including cell-specific delivery coupling ligands or antibodies with nanodevices to improve siRNA efficiency and specificity.
Descrição
Palavras-chave
Gene therapy, nanoparticles, multifunctional, polycations, stimuli-responsive polymers, siRNA delivery
Como citar
Current Gene Therapy. Sharjah: Bentham Science Publ Ltd, v. 13, n. 5, p. 358-369, 2013.