Bioactive Secondary Metabolites from Phomopsis sp., an Endophytic Fungus from Senna spectabilis
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Data
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Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Mdpi Ag
Tipo
Artigo
Direito de acesso
Acesso aberto
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Resumo
Chemical investigation of an acetonitrile fraction from the endophytic fungus Phomopsis sp. led to the isolation of the new natural product 2-hydroxy-alternariol (7) together with the known compounds cytochalasins J (1) and H (2), 5'-epialtenuene (3) and the mycotoxins alternariol monomethyl ether (AME, 4), alternariol (AOH, 5) and cytosporone C (6). The structure of the new compound was elucidated by using 1-D and 2-D NMR (nuclear magnetic resonance) and high resolution mass spectrometry. The cytochalasins J (1) and H (2) and AOH (5) exhibited potent inhibition of the total ROS (reactive oxygen species) produced by stimulated human neutrophils and acted as potent potential anti-inflammatory agents. Moreover, cytochalasin H (2) demonstrated antifungal and acetylcholinesterase enzyme (AChE) inhibition in vitro.
Descrição
Palavras-chave
secondary metabolites, bioactivities, endophytic fungi, Phomopsis sp., Senna spectabilis
Idioma
Inglês
Citação
Molecules. Basel: Mdpi Ag, v. 19, n. 5, p. 6597-6608, 2014.
