Perfil dos hormônios da tireoide em pacientes com câncer de mama em estado de menopausa
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Data
2012-06-01
Autores
Conde, Sandro Jose [UNESP]
Melo Luvizotto, Renata de Azevedo [UNESP]
de Sibio, Maria Teresa [UNESP]
Saraiva, Patricia Pinto
Brentani, Maria Mitzi
Nogueira, Célia Regina [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Sbem-soc Brasil Endocrinologia & Metabologia
Resumo
Objective: The aim of this study was to determine thyroid hormone (TH) profile in postmenopausal patients with breast cancer (BC). Subjects and methods: 12 CaM patients stages I or II, without interventions that could interfere with tumor progression were selected, as well as and a control group with 18 postmenopausal women without CaM. We measured serum anti-thyroperoxidase antibody (TPOAB), thyroid-stimulating hormone (TSH), free thyroxine (T4L), estradiol (E2), follicle-stimulating hormone (FSH), and luteinizing hormone (LH), before and after surgery, besides immunohistochemistry for estrogen (ER) and progesterone (PR) receptors. Results: Four patients with CaM showed changes in thyroid hormone profile: two had hyperthyroidism, one hypothyroidism, and one was positive for TPO-AB. All of them positive for ER and PR.TSH levels in breast cancer patients were not different from levels found in the control group (1.89 +/- 1.56 vs. 2.86 +/- 3.12 mIU/mL), but the levels of T4L in patients with CaM were statistically higher than those of the control group (1.83 +/- 0.57 vs. 1.10 +/- 0.20 ng/dL). Conclusion: These results reinforce the need for assessment of thyroid status in CaM patients, since in the absence of E2, changes in clinical HTs can act in E2-controlled processes. Arq Bras Endocrinol Metab. 2012;56(4):238-43
Descrição
Palavras-chave
Thyroid hormones, breast neoplasms, hyperthyroidism, postmenopause
Como citar
Arquivos Brasileiros de Endocrinologia E Metabologia. Rio de Janeiro, Rj: Sbem-soc Brasil Endocrinologia & Metabologia, v. 56, n. 4, p. 238-243, 2012.