Pharmaceutical applications of AC Biosusceptometry

Nenhuma Miniatura disponível

Data

2010-01-01

Autores

Cora, Luciana A. [UNESP]
Americo, Madileine F. [UNESP]
Romeiro, Fernando Gomes [UNESP]
Oliveira, Ricardo B. [UNESP]
Miranda, Jose Ricardo A. [UNESP]

Título da Revista

ISSN da Revista

Título de Volume

Editor

Elsevier B.V.

Resumo

AC Biosusceptometry offers an alternative to investigate noninvasively and without ionizing radiation the behavior of solid dosage forms in vitro and in the human gastrointestinal tract. This versatility allowed applying this technique in a wide field ranging from characterization of the disintegration process to elucidation of how the physiological parameters can interfere with pharmaceutical processes. It is increasingly important to understand how oral solid dosage forms behave in the human gastrointestinal tract. Once labelled, magnetic dosage forms provide ail excellent opportunity to investigate complexes' interactions between dosage form and gastrointestinal physiology. In this paper, basic principles of this biomagnetic instrumentation and of the quantification based on magnetic images are reviewed. Also will be presented are some of the most recent applications of AC Biosusceptometry in the pharmaceutical research including oesophageal transit, gastric emptying and transit time of multiparticulate dosage forms, hydrophilic matrices and disintegration of tablets. (C) 2009 Elsevier B.V. All rights reserved.

Descrição

Palavras-chave

Biosusceptometry, Gastrointestinal tract, Solid dosage forms, Imaging, Disintegration

Como citar

European Journal of Pharmaceutics and Biopharmaceutics. Amsterdam: Elsevier B.V., v. 74, n. 1, p. 67-77, 2010.