Synthesis and antimycobacterial activity of new pyrazolate-bridged dinuclear complexes of the type [Pd(mu-L)(N-3)(PPh3)](2) (PPh3 = triphenylphosphine; L = pyrazolates)
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Elsevier B.V.
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Binuclear compounds of the type [Pd(mu-L)(N-3)(PPh3)](2) {L = pyrazolate (1); 3,5-dimethylpyrazolate (2); 4-iodopyrazolate (3); PPh3 = triphenylphosphine} were synthesized and characterized by elemental analyses, infrared and H-1 and P-31{H-1} NMR spectroscopies. The crystal and molecular structures of the complex [Pd(mu-dmPz)(N-3)(PPh3)](2) (2) were determined by single-crystal X-ray diffraction techniques. In vitro antimycobacterial evaluation demonstrated that compound [Pd(mu-Pz)(N-3)(PPh3)](2) (1) displayed a MIC of 8.16 mu M, being more active than some commonly used anti-TB drugs and other Pd(II) complexes. (C) 2014 Elsevier B.V. All rights reserved.
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Binuclear Pd(II) compounds, Triphenylphosphine, Pyrazolates, Mycobacterium tuberculosis
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Inglês
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Inorganic Chemistry Communications. Amsterdam: Elsevier Science Bv, v. 48, p. 153-155, 2014.
