Jatrophidin I, a cyclic peptide from Brazilian Jatropha curcas L.: Isolation, characterization, conformational studies and biological activity
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Elsevier B.V.
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Resumo
A cyclic peptide, jatrophidin I, was isolated from the latex of Jatropha curcas L. Its structure was elucidated by extensive 2D NMR spectroscopic analysis, with additional conformational studies performed using Molecular Dynamics/Simulated Annealing (MD/SA). Jatrophidin I had moderate protease inhibition activity when compared with pepstatin A; however, the peptide was inactive in antimalarial, cytotoxic and antioxidant assays. (C) 2014 Elsevier Ltd. All rights reserved.
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Jatropha curcas, Euphorbiaceae, Cyclic peptides, Protease inhibition activity
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Inglês
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Phytochemistry. Oxford: Pergamon-elsevier Science Ltd, v. 107, p. 91-96, 2014.
