Jatrophidin I, a cyclic peptide from Brazilian Jatropha curcas L.: Isolation, characterization, conformational studies and biological activity
Nenhuma Miniatura disponível
Data
2014-11-01
Autores
Altei, Wanessa F. [UNESP]
Picchi, Douglas G. [UNESP]
Abissi, Barbara M. [UNESP]
Giesel, Guilherme M.
Flausino, Otavio [UNESP]
Reboud-Ravaux, Michele
Verli, Hugo
Crusca, Edson [UNESP]
Silveira, Edilberto R.
Cilli, Eduardo M. [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Elsevier B.V.
Resumo
A cyclic peptide, jatrophidin I, was isolated from the latex of Jatropha curcas L. Its structure was elucidated by extensive 2D NMR spectroscopic analysis, with additional conformational studies performed using Molecular Dynamics/Simulated Annealing (MD/SA). Jatrophidin I had moderate protease inhibition activity when compared with pepstatin A; however, the peptide was inactive in antimalarial, cytotoxic and antioxidant assays. (C) 2014 Elsevier Ltd. All rights reserved.
Descrição
Palavras-chave
Jatropha curcas, Euphorbiaceae, Cyclic peptides, Protease inhibition activity
Como citar
Phytochemistry. Oxford: Pergamon-elsevier Science Ltd, v. 107, p. 91-96, 2014.