In Vitro Antibacterial Activity of Prenylated Guanidine Alkaloids from Pterogyne nitens and Synthetic Analogues
Nenhuma Miniatura disponível
Data
2014-08-01
Autores
Coqueiro, Aline [UNESP]
Regasini, Luis Octavio [UNESP]
Stapleton, Paul
Bolzani, Vanderlan da Silva [UNESP]
Gibbons, Simon
Título da Revista
ISSN da Revista
Título de Volume
Editor
Amer Chemical Soc
Resumo
The present investigation deals with the antibiotic activity of eight natural guanidine alkaloids and two synthetic analogues against a variety of clinically relevant methicillin-resistant Staphylococcus aureus strains. Galegine (1) and pterogynidine (2) were the most potent compounds, with a minimum inhibitory concentration of 4 mg/L, to all tested strains. The preliminary chemical features correlating to anti-MRSA activity showed that the size of the side chain and the substitution pattern in the guanidine core played a key role in the antibacterial activity of the imino group. Guanidine alkaloids 1 and 2 are promising molecular models for further synthetic derivatives and, thus, for medicinal chemistry studies.
Descrição
Palavras-chave
Como citar
Journal Of Natural Products. Washington: Amer Chemical Soc, v. 77, n. 8, p. 1972-1975, 2014.