Clonal monosomy of chromosome 21 in a case of myelodysplastic syndrome
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Data
2011-01-01
Autores
Freitas, P. C. [UNESP]
Carvalho-Salles, A. B.
Mendiburu, C. F. [UNESP]
Ricci, O.
Fett-Conte, A. C.
Título da Revista
ISSN da Revista
Título de Volume
Editor
Funpec-editora
Resumo
This study reports on a cytogenetic finding in a bone marrow examination of a 47-year-old male patient treated in the Hematology and Blood Transfusion Service of the Hospital de Base in Sao Jose do Rio Preto, Sao Paulo State, Brazil. The only alteration found at diagnosis of myelodysplastic syndrome (MDS) subtype refractory anemia with excess blasts (RAEB-2) was clonal monosomy of chromosome 21. The patient evolved to acute myeloid leukemia type M2 and died nine months after diagnosis. Clonal monosomy of chromosome 21, as the only cytogenetic abnormality in MDS, has only been reported three times previously. This uncommon cytogenetic abnormality in MDS has been associated with a poor clinical course, although more data will be needed to determine if this prognosis is invariable.
Descrição
Palavras-chave
Myelodysplastic syndrome, Monosomy 21, Clonal chromosomal abnormalities
Como citar
Genetics And Molecular Research. Ribeirao Preto: Funpec-editora, v. 10, n. 4, p. 2718-2720, 2011.