Effects of age on aerobic capacity in heart failure patients under beta-blocker therapy: Possible impact in clinical decision-making?
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Data
2013-01-01
Autores
Ciolac, Emmanuel Gomes [UNESP]
Bocchi, Edimar Alcides
Fernandes da Silva, Miguel Morita
Tavares, Aline Cristina
Teixeira-Neto, Iram Soares
Guimaraes, Guilherme Veiga
Título da Revista
ISSN da Revista
Título de Volume
Editor
Via Medica
Resumo
Background: Heart failure (HF) is associated with impaired maximal aerobic capacity as indicated by decreases in peak oxygen uptake (peak VO2). Considering that aging by itself has a negative effect on this variable, the evaluation of maximum capacity is often questioned because current predicted peak VO2 is based on subjects without heart disease or beta-blocker therapy. In contrast, if decline in predicted and attained peak VO2 were age-related, proportionally, loss of aerobic function (predicted peak VO2, %) would remain stable over time in these patients. The purpose of this investigation is to assess the effects of age on peak VO2 in HF patients taking beta-blockers.Methods: We retrospectively evaluated 483 (132 female) patients (aged 20-88 years, LVEF 31 +/- 11%) with non-ischemic (n = 362), ischemic (n = 74) and Chagas-related HF (n = 47) who had been submitted to an incremental cardiopulmonary exercise testing on a motorized treadmill. Linear regression was used to develop the equation to predict peak VO2, based on age.Results: Peak VO2 decreased 0.9 mL/min/kg per age-decade, maximum HR also decreased with aging and VE/VCO2 slope was similar among all decades. The predicted new beta-blocker equation to peak VO2bb was 20.934 - 0.092 x age.Conclusions: Clinical interpretation of aerobic capacity impairment is influenced by aging in HF patients. This evidence must be considered when using peak VO2 for prognostic stratification and clinical decision-making in patients with HF under beta-blocker therapy.
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Palavras-chave
aging, beta-blocker therapy, cardiopulmonary exercise test, cardiorespiratory fitness, heart failure
Como citar
Cardiology Journal. Gdansk: Via Medica, v. 20, n. 6, p. 655-661, 2013.