Influence of Maternal Hyperglycemia on IL-10 and TNF-alpha Production: The Relationship with Perinatal Outcomes
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Data
2012-06-01
Autores
Moreli, Jusciele Brogin [UNESP]
Morceli, Glilciane [UNESP]
De Luca, Ana Karina C. [UNESP]
Magalhaes, Claudia G. [UNESP]
Costa, Roberto Antonio de Araújo [UNESP]
Damasceno, Débora Cristina [UNESP]
Rudge, Marilza Vieira Cunha [UNESP]
Calderon, Iracema de Mattos Paranhos [UNESP]
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Editor
Springer/plenum Publishers
Resumo
Aims This study was conducted to evaluate maternal and placental concentrations of interleukin 10 (IL-10) and tumor necrosis factor-alpha (TNF-alpha) in pregnant women with glycemic mean (GM) < or >= 100 mg/dL, as well as correlate IL-10 and TNF-alpha placental concentrations with perinatal outcomes.Methods One hundred eighty-six pregnant women were distributed in groups determined by a GM < 100 mg/dL or a GM >= 100 mg/dL. The GM, HbA1c levels, maternal and placental concentrations of IL-10 and TNF-alpha, and the correlation of placental cytokines with perinatal outcomes were evaluated.Results In maternal blood, the lowest concentrations of IL-10 (p=00.0019) and TNF-alpha (p=0.0185) were observed in the GM >= 100-mg/dL group. The placentas from GM >= 100 mg/dL group exhibited higher TNF-alpha concentrations (p=0.0385). Placental IL-10 directly correlated with hemoglobin (r=0.63; p=0.02) and insulin (r=0.78; p=0.01) levels in the umbilical cord and with 1-min (r=0.53; p=0.0095) and 5-min (r=0.69; p=0.0003) Apgar scores. Placental TNF-alpha displayed a tendency to inversely correlate with fetal weight (r=-0.41; p=0.05).Conclusion Compared to GM<100 mg/dL, GM >= 100 mg/dL was associated with a reduction in maternal IL-10 and TNF-alpha concentrations and increased placental TNF-alpha production. Placental IL-10 production was similar in both groups studied and directly correlated with hemoglobin and umbilical cord insulin levels, as well as with the 1- and 5-min Apgar scores.
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Palavras-chave
Cytokines, diabetes, mild gestational hyperglycemia, placenta, perinatal outcomes
Como citar
Journal of Clinical Immunology. New York: Springer/plenum Publishers, v. 32, n. 3, p. 604-610, 2012.