Hipertensão arterial experimental e prenhez em ratas: repercussões no peso da placenta e no índice placentário
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Data
2001-03-01
Autores
Dias, Rogerio [UNESP]
Rudge, Marilza Vieira Cunha [UNESP]
Trindade, José Carlos Souza [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
Resumo
Objetivo: estudar as repercussões da hipertensão sobre o peso da placenta e índice placentário. Métodos: foram utilizadas 82 ratas virgens da linhagem Wistar em idade de reprodução. Após a indução da hipertensão arterial experimental (Modelo Goldblatt I -- 1 rim-1 clipe) as ratas foram sorteadas para compor os 4 grandes grupos experimentais (controle, manipulação, nefrectomia e hipertensão). A seguir, as ratas foram distribuídas por sorteio em 8 subgrupos, sendo quatro prenhes (P) e quatro não-prenhes. Após acasalamento, dos quatro grupos prenhes obtivemos com o nascimento dos recém-nascidos (RN) os seguintes grupos: RN-C, RN-M, RN-N e RN-H, respectivamente, controle, manipulação, nefrectomizado e hipertenso. Resultados: quanto ao peso da placenta, o do grupo RN-C foi estatisticamente maior que o de todos os demais grupos. Por outro lado, verifica-se que o peso das placentas provenientes do grupo RN-M foi maior que o dos grupos RN-N e RN-H, os quais não diferiram entre si. Os índices placentários dos grupos P-C (Md = 0,1085) e P-M (Md = 0,1110) não diferiram entre si, mas foram menores que os dos grupos P-N (Md = 0,1175) e P-H (Md = 0,1211), os quais também não diferiram entre si. Conclusões: a hipertensão e a nefrectomia unilateral determinaram redução do peso das placentas e aumento do índice placentário, evidenciando repercussões no desenvolvimento placentário e fetal.
Purpose: to study the repercussion regarding placental weight and placental index determined by induced experimental hypertension in rats. Methods: a total of 82 rats in reproductive age were used. They were randomly assigned to 4 different groups (control, handled, nephrectomy and hypertension) and renal hypertension was produced by a controlled constriction of the main left renal artery, according to the technique described by Goldblatt, and contralateral nephrectomy (Goldblatt I one kidney--one clip model). Furthermore, they were distributed into non-pregnant groups and pregnant (P) groups. From the pregnant groups, the following newborn groups were obtained: RN-C (control -- newborn group from the pregnant rats without surgical treatment), RN-M (manipulation -- newborn group from the pregnant rats with surgical manipulation), RN-N (nephrectomy -- newborn group from the pregnant rats with nephrectomy) and RN-H (hypertension -- newborn group from pregnant rats with hypertension). Results: the RN-C newborn group showed placental weight higher than the other three groups. on the other hand, it was possible to observe that the placental weight of the RN-M was higher than that of RN-N and RN-H, respectively, but no difference was observed between the RN-N and RN-H groups. The placental index showed no difference between P-C (Md = 0.1085) and P-M (Md = 0.1110), and also between P-N (0.1175) and P-H (0.1211), but it was observed that the placental indexes of P-C and P-M were smaller that those of P-N and P-H. Conclusion: unilateral nephrectomy and hypertension determined a reduction in placental weight and an increase in the placental index, showing a repercussion regarding placental and fetal development.
Purpose: to study the repercussion regarding placental weight and placental index determined by induced experimental hypertension in rats. Methods: a total of 82 rats in reproductive age were used. They were randomly assigned to 4 different groups (control, handled, nephrectomy and hypertension) and renal hypertension was produced by a controlled constriction of the main left renal artery, according to the technique described by Goldblatt, and contralateral nephrectomy (Goldblatt I one kidney--one clip model). Furthermore, they were distributed into non-pregnant groups and pregnant (P) groups. From the pregnant groups, the following newborn groups were obtained: RN-C (control -- newborn group from the pregnant rats without surgical treatment), RN-M (manipulation -- newborn group from the pregnant rats with surgical manipulation), RN-N (nephrectomy -- newborn group from the pregnant rats with nephrectomy) and RN-H (hypertension -- newborn group from pregnant rats with hypertension). Results: the RN-C newborn group showed placental weight higher than the other three groups. on the other hand, it was possible to observe that the placental weight of the RN-M was higher than that of RN-N and RN-H, respectively, but no difference was observed between the RN-N and RN-H groups. The placental index showed no difference between P-C (Md = 0.1085) and P-M (Md = 0.1110), and also between P-N (0.1175) and P-H (0.1211), but it was observed that the placental indexes of P-C and P-M were smaller that those of P-N and P-H. Conclusion: unilateral nephrectomy and hypertension determined a reduction in placental weight and an increase in the placental index, showing a repercussion regarding placental and fetal development.
Descrição
Palavras-chave
Hipertensão e gravidez, Hipertensão, alterações placentárias, Hipertensão experimental em ratas, Hypertension and pregnancy, Hypertension, placental disorders, Experimental hypertension in rats
Como citar
Revista Brasileira de Ginecologia e Obstetrícia. Federação Brasileira das Sociedades de Ginecologia e Obstetrícia, v. 23, n. 2, p. 87-91, 2001.