Repair of the anophthalmic cavity of rats with synthetic hydroxyapatite
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Data
1997-10-01
Autores
Ranzani, J. J. [UNESP]
Rahal, Sheila Canevese [UNESP]
Schellini, Silvana Artioli [UNESP]
Marques, M. E. A. [UNESP]
Taga, E. M.
Título da Revista
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Título de Volume
Editor
Associação Brasileira de Divulgação Científica (ABRADIC)
Resumo
We placed spheres of synthetic hydroxyapatite (calcium chloride combined with sodium phosphate) in the eviscerated or enucleated orbital cavity of rats in order to evaluate the biocompatibility of this material with the orbital cavity. The study was conducted on 50 albino rats, 25 of which were submitted to enucleation and 25 to evisceration of one eye. The animals were sacrificed 7, 15, 21, 30 and 60 days after surgery and the orbital content was submitted to histopathological examination. A reaction of the young granulation tissue type was observed first. The hydroxyapatite was gradually surrounded by a granulomatous macrophage inflammatory response and covered with dense connective tissue that formed a sort of mesh septating and supporting progressively smaller blocks of the substance. The same type of reaction was observed in the enucleated and eviscerated cavities. We conclude that synthetic hydroxyapatite is an inert nonallergenic material which is appropriate for volume replacement in the anophthalmic cavity
Descrição
Palavras-chave
synthetic hydroxyapatite, reconstruction of the anophthalmic cavity, experimental rats
Como citar
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 30, n. 10, p. 1181-1186, 1997.