Genotoxicity of antimicrobial endodontic compounds by single cell gel (comet) assay in Chinese hamster ovary (CHO) cells
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Data
2005-05-01
Autores
Ribeiro, D. A.
Scolastici, C.
de Lima, PLA
Marques, MEA
Salvadori, Daisy Maria Favero [UNESP]
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Mosby, Inc
Resumo
Objective. In the current study, the potential DNA damage associated with exposure to a number of antimicrobial endodontic compounds was assessed by the single cell gel (comet) assay in vitro.Study design. Chinese hamster ovary (CHO) cells were exposed to formocresol, paramonochlorophenol, calcium hydroxide, or chlorhexidine at final concentration ranging from 0.01% to 1%.Results. Formocresol, paramonochlorophenol, and calcium hydroxide, as well as chlorhexidine in all concentrations tested did not contribute to the DNA damage.Conclusion. These findings are clinically relevant since they represent an important contribution to the correct evaluation of the potential health risk associated with exposure to dental agents.
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Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics. St Louis: Mosby, Inc., v. 99, n. 5, p. 637-640, 2005.