Pamidronate attenuates diastolic dysfunction induced by myocardial infarction associated with changes in geometric patterning
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Data
2015-01-01
Autores
Gonçalves, Andrea de Freitas [UNESP]
Congio, Luiz Henrique [UNESP]
Santos, Priscila Portugal dos [UNESP]
Rafacho, Bruna Paola Murino [UNESP]
Pereira, Bruna Letícia Buzati [UNESP]
Claro, Renan Floret Turini [UNESP]
Costa, Nara Aline [UNESP]
Chiuso-Minicucci, Fernanda [UNESP]
Azevedo, Paula Schmidt [UNESP]
Polegato, Bertha Furlan [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Karger
Resumo
Background/Aims: The aim of this study was to evaluate the influence of pamidronate on ventricular remodeling after myocardial infarction. Methods: Male Wistar rats were assigned to four groups: a sham group, in which animals were submitted to simulated surgery and received weekly subcutaneous injection of saline (S group; n=14); a group in which animals received weekly subcutaneous injection of pamidronate (3 mg/kg of body weight) and were submitted to simulated surgery (SP group, n=14); a myocardial infarction group, in which animals were submitted to coronary artery ligation and received weekly subcutaneous injection of saline (MI group, n=13); and a myocardial infarction group with pamidronate treatment (MIP group, n=14). The rats were observed for three months. Results: Animals submitted to MI had left chamber enlargement and worse diastolic and systolic function compared with SHAM groups. E/A ratio, LV posterior and relative wall thickness were lower in the MIP compared with the MI group. There was no interaction between pamidronate administration and MI on systolic function, myocyte hypertrophy, collagen content, and calcium handling proteins. Conclusion: Pamidronate attenuates diastolic dysfunction following MI.
Descrição
Palavras-chave
Ventricular remodeling, Bisphosphonates, Calcium handling proteins
Como citar
Cellular Physiology And Biochemistry. Basel: Karger, v. 35, n. 1, p. 259-269, 2015.