Publicação: Pyridinic analog of the natural product (-)-spectaline as potential adjuvant for the treatment of central nervous system disorders
Nenhuma Miniatura disponível
Data
2015-05-15
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Elsevier B.V.
Tipo
Artigo
Direito de acesso
Acesso restrito
Resumo
Previously we designed a series of pyridinic anticholinesterasic compounds based on molecular hybridization between tacrine and the natural piperidine alkaloid (-)-3-O-acetylspectaline isolated from Senna spectabilis. Based on the information that the cholinergic system has an important role in the treatment of schizophrenia and depression, we herein report the evaluation of a series of pyridinic compounds in animal models for antipsychotic and antidepressant-like activities. Compound 2 decreased the immobility time of mice in the forced swimming test (5 and 10 mg/kg p.o.) and prevented the climbing behavior induced by apomorphine (10 mg/kg, p.o.), without impairing animals locomotor activity.
Descrição
Idioma
Inglês
Como citar
Bioorganic & Medicinal Chemistry Letters. Oxford: Pergamon-elsevier Science Ltd, v. 25, n. 10, p. 2247-2250, 2015.
