Pyridinic analog of the natural product (-)-spectaline as potential adjuvant for the treatment of central nervous system disorders
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Data
2015-05-15
Autores
Valli, Marilia [UNESP]
Betti, Andresa Heemann
Danuello, Amanda
Pivatto, Marcos
Centurião, Fernanda
Antonio, Camila Boque
Rates, Stela Maris Kuze
Bolzani, Vanderlan da Silva [UNESP]
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Editor
Elsevier B.V.
Resumo
Previously we designed a series of pyridinic anticholinesterasic compounds based on molecular hybridization between tacrine and the natural piperidine alkaloid (-)-3-O-acetylspectaline isolated from Senna spectabilis. Based on the information that the cholinergic system has an important role in the treatment of schizophrenia and depression, we herein report the evaluation of a series of pyridinic compounds in animal models for antipsychotic and antidepressant-like activities. Compound 2 decreased the immobility time of mice in the forced swimming test (5 and 10 mg/kg p.o.) and prevented the climbing behavior induced by apomorphine (10 mg/kg, p.o.), without impairing animals locomotor activity.
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Palavras-chave
Pyridinic alkaloid analogs, Antidepressant-like activity, Antipsychotic, Apomorphine-induced climbing, Forced swimming test
Como citar
Bioorganic & Medicinal Chemistry Letters. Oxford: Pergamon-elsevier Science Ltd, v. 25, n. 10, p. 2247-2250, 2015.