KSHV genotypes A and C are more frequent in Kaposi sarcoma lesions from Brazilian patients with and without HIV infection, respectively
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Data
2011-02-01
Autores
Silva, Suzane Ramos de [UNESP]
Silva, Ana Paula Ferraz da [UNESP]
Bacchi, Maura Moscardi [UNESP]
Bacchi, Carlos Eduardo [UNESP]
Oliveira, Deilson Elgui de [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Elsevier B.V.
Resumo
The present study aimed to evaluate the frequency of KSHV genotypes isolated from Kaposi sarcoma (KS) lesions in patients from Brazil. Fifty KS cases were evaluated. The most frequently detected viral genotypes were A (50.0%) and C (48.0%); the B genotype was isolated only in one case (2.0%). Noteworthy, there was a significant predominance of A genotypes in KS lesions from HIV-positive patients, whereas C genotypes were found mostly in the HIV-negative setting. This finding supports the hypothesis that distinct KSHV genotypes have a non-random distribution in KS, which might be attributable to unique biological properties. (C) 2010 Elsevier B.V. All rights reserved.
Descrição
Palavras-chave
KSHV, HHV-8, Kaposi sarcoma, Viral genotyping
Como citar
Cancer Letters. Clare: Elsevier B.V., v. 301, n. 1, p. 85-94, 2011.