Publicação: Role of the adrenergic pathways of the lateral hypothalamus on water intake and pressor response induced by the cholinergic activation of the medial septal area in rats
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Data
1994-02-14
Orientador
Coorientador
Pós-graduação
Curso de graduação
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Editor
Elsevier B.V.
Tipo
Artigo
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Acesso restrito
Resumo
In the present experiments, we investigated a possible involvement of noradrenergic receptors of the lateral hypothalamus (LH) in the water intake and pressor response induced by cholinergic stimulation of the medial septal area (MSA) in rats. The cholinergic agonist carbachol (2 nmol) injected into the MSA induced water intake and pressor response. The injection of an α2-adrenergic agonist, clonidine (20 and 40 nmol), but not of an α1-adrenergic agonist, phenylephrine (80 and 160 nmol), into the LH inhibits the water intake induced by carbachol injected into the MSA. The injection of clonidine or phenylephrine into the LH produced no change in the MAP increase induced by carbachol injected into the MSA. The present results suggest that adrenergic pathways involving the LH are important for the water intake, but not for the pressor response, induced by cholinergic activation of the MSA. © 1994.
Descrição
Palavras-chave
Adrenergic receptor, Arterial pressure, Cholinergic receptor, Thirst, Water intake, Alpha 1 adrenergic receptor, Alpha 2 adrenergic receptor, Alpha adrenergic receptor blocking agent, Alpha adrenergic receptor stimulating agent, Carbachol, Clonidine, Phenylephrine, Animal experiment, Blood pressure, Cholinergic system, Controlled study, Fluid intake, Intracerebral drug administration, Lateral hypothalamus, Male, Nonhuman, Priority journal, Rat, Septum nucleus, Animal, Blood Pressure, Carbachol, Clonidine, Drinking, Hypothalamic Area, Lateral, Male, Neural Pathways, Parasympathomimetics, Phenylephrine, Rats, Rats, Inbred Strains, Septum Pellucidum, Support, Non-U.S. Gov't, Sympathetic Nervous System
Idioma
Inglês
Como citar
Neuroscience Letters, v. 167, n. 1-2, p. 153-155, 1994.
