Cardiac remodeling induced by smoking: concepts, relevance, and potential mechanisms
Carregando...
Data
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Inflammation & Allergy Drug Targets
Tipo
Artigo
Direito de acesso
Acesso restrito
Resumo
Cardiac or ventricular remodeling is characterized by molecular, cellular, and interstitial alterations that lead to changes in heart size, mass, geometry and function in response to a given insult. Currently, tobacco smoke exposure is recognized as one of these insults. Indeed, tobacco smoke exposure induces the enlargement of the left-sided cardiac chambers, myocardial hypertrophy, and ventricular dysfunction. Potential mechanisms for these alterations include hemodynamic and neurohormonal changes, oxidative stress, inflammation, nitric oxide bioavailability, matrix metalloproteinases and mitogen-activated protein kinase activation. This review will focus on the concepts, relevance, and potential mechanisms of cardiac remodeling induced by tobacco smoke.
Descrição
Palavras-chave
Matrix metalloproteinases, Oxidative stress, Tobacco smoke exposure, Ventricular remodeling, Cardiac Remodeling, Heart size, Myocardial hypertrophy, Ventricular dysfunction, Hemodynamic, Neurohormonal changes, Oxidative stress, Inflammation, Mitogen-activated protein kinase activation
Idioma
Inglês
Citação
Inflammation & Allergy Drug Targets, v. 11, n. 6, p. 442-447, 2012.
