TNF-alpha and IL-6 immunohistochemistry in rat renal tissue experimentaly infected with Leptospira interrogans serovar Canicola

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Data

2008-01-01

Autores

Marinho, Márcia [UNESP]
Monteiro, Cristina Maria Rodrigues [UNESP]
Peiró, Juliana Regina [UNESP]
Machado, Gisele Fabrino [UNESP]
Oliveira-Junior, I. S.

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ISSN da Revista

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Editor

Universidade Estadual Paulista (Unesp), Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP)

Resumo

Leptospirosis is a public health problem worldwide and its etiology remains unclear. Its pathogenesis involves a complex interaction between host and infecting microorganism. The inflammatory reaction that controls the infection process also underscores many pathophysiological events occurring in leptospirosis. We investigated the presence of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in renal tissues by immunohistochemical and histopathological examination in animals experimentally inoculated with Leptospira serovar Canicola. All the tests were carried out 2, 7, 14, 21 or 28 days after inoculation. Although TNF-alpha and IL-6 had been detected in tissues throughout the observation period, these cytokines appeared more intensely during the initial phase of infection. Therefore, both TNF-alpha and IL-6 were associated with the immunopathogenesis of leptospirosis. This profile suggests a high immunocellular response throughout the early infection stages followed by subsequent humoral response.

Descrição

Palavras-chave

IL-6, Immunohistochemistry, Leptospirosis, Mice, TNF-α, Animalia, Leptospira, Leptospira interrogans, Leptospira interrogans serovar Canicola, Mus, Rattus

Como citar

Journal of Venomous Animals and Toxins Including Tropical Diseases. Botucatu: Cevap-unesp, v. 14, n. 3, p. 533-540, 2008.