Development and analysis of formulations to the delivery of caffeine for the treatment of gynoid lipodystrophy
Nenhuma Miniatura disponível
Data
2014
Autores
Isaac, Vera Lucia Borges [UNESP]
Chiari, Bruna Galdorfini
Boschetti, Viviane Cristine
Uema, Marisa Keiko
Almeida, Maria Gabriela José de
Corrêa, Marcos Antonio
Kedor-Hackmann, Erika Rosa Maria
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
This study aimed to investigate the kinetics of the in vitro release of caffeine in various excipients, and to perform the rheological characterization of these excipients. In vitro release experiments were performed using cellulose membranes in a diffusion apparatus adapted. In order to characterize the rheological behavior of the excipients, a viscometer was used to obtain the flow curves. The data obtained in the present study suggest that caffeine release from the various excipients is dependent of the solubility of caffeine in the excipient (or in the phase of the excipient where caffeine were solubilized) and of the rheological features, mainly the viscosity.
Descrição
Palavras-chave
Caffeine, Excipient, Gynoide lipodystrophy, In vitro release
Como citar
International Journal of Drug Delivery Science, v. 1, n. 1, p. 14-20, 2014.