Publicação: Função de PD-1 na apoptose de linfócitos T na leishmaniose visceral canina
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Data
2015-12-04
Autores
Orientador
Lima, Valéria Marçal Felix de 
Coorientador
Pós-graduação
Ciência Animal - FMVA
Curso de graduação
Título da Revista
ISSN da Revista
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Editor
Universidade Estadual Paulista (Unesp)
Tipo
Dissertação de mestrado
Direito de acesso
Acesso aberto
Resumo
Dogs infected with Leishmania infantum showed a reduction in the number of lymphocytes T. PD-1 (Programmed cell death 1) a new member of the B7-CD28 family, it is expressed by cells of the immune system and its binding to PD-L1 (CD274) or PD-L2 (CD273) induces deactivation of T cells or apoptosis. This study aimed to evaluate the PD-1 expression and its ligands as well as their role in T lymphocyte induction of apoptosis, TNF-α and IL-4 secretion, nitric oxide production and parasite load in dogs with visceral leishmaniasis. We observed that in canine visceral leishmaniasis PD-1 and its ligands involved in induction of apoptosis of T lymphocytes, are regulating the nitric oxide production, TNF-α, IL-4, as well as the parasitic load. This study helps to clarify the mechanism of immune response and immunotherapeutic drugs such as blocking monoclonal antibodies that can influence the LVC
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Idioma
Português
Como citar
CHIKU, Vanessa Marim. Função de PD-1 na apoptose de linfócitos T na leishmaniose visceral canina. 2015. 67 f. Dissertação (mestrado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicina Veterinária, 2015.
