Insulin signal decrease in muscle but not in the liver of castrated male rats from chronic exposure to fluoride
Nenhuma Miniatura disponível
Data
2010-01-01
Autores
Chiba, Fernando Yamamoto [UNESP]
Colombo, Natalia Helena [UNESP]
Shirakashi, Daisy Jaqueline [UNESP]
de Souza Gomes, Wendrew Douglas [UNESP]
Moimaz, Suzely Adas Saliba [UNESP]
Garbin, Clea Adas Saliba [UNESP]
Silva, Cristina Antoniali [UNESP]
Sumida, Doris Hissako [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Int Soc Fluoride Research
Resumo
With half the animals as controls without fluoride (F) in their drinking water, 16 of 32 seven-week-old castrated male Wistar rats were administered NaF in their drinking water and F contained in food pellets (estimated total F intake: 4.0 mg F/kg bw/day). After 42 days, determinations were made of the insulin receptor substrate (pp185-IRS-1/IRS/2), tyrosine phosphorylation status, and the extent of glycemia and insulinemia. This chronic treatment with F promoted: 1) decrease in the pp185 tyrosine phosphorylation status in the muscle tissue but not in the liver; 2) increase in the plasma F level; 3) no alteration in glycemia and insulinemia; 4) an increase in insulin resistance.
Descrição
Palavras-chave
Fluoride, Insulin receptor substrate, Insulin sensitivity, Insulin signal, Rats and insulin
Como citar
Fluoride. Ocean View: Int Soc Fluoride Research, v. 43, n. 1, p. 25-30, 2010.