Cyclosporin A-induced gingival overgrowth in renal transplant patients
Nenhuma Miniatura disponível
Data
2003-01-01
Autores
Afonso, M.
de Oliveira Bello, V
Shibli, J. A.
Sposto, M. R.
Título da Revista
ISSN da Revista
Título de Volume
Editor
Amer Acad Periodontology
Resumo
Background: the incidence of gingival overgrowth (GO) associated with the use of cyclosporin A (CsA) is controversial. In the present study, we determined the incidence of GO in Brazilian renal transplant patients treated with CsA and the possible associations between periodontal and pharmacological variables.Methods: the test group consisted of 20 renal transplant patients, and the control group included 20 non-transplant patients. Periodontal conditions were evaluated based on the plaque index (PI), gingival index (GI), probing depth (PD), and the rate of gingival overgrowth, together with pharmacological variables (daily CsA dose and duration of treatment).Results: A significant difference in PI (P<0.0001) and PD (P<0.0001) was observed between groups, while GI (P=0.15) did not differ significantly. Using the Pearson correlation coefficient, a significant correlation was observed not only between GI (P<0.001; r=0.8141) and GO, but also for PD (P<0.001; r=0.866) and GO. The other correlations were not statistically significant.Conclusions: We conclude that GO induced by CsA may vary according to the individual sensitivity of each patient and may or may not be correlated with other local factors (periodontal variables).
Descrição
Palavras-chave
clinical evaluation/periodontal diseases, cyclosporin A/adverse effects, gingival hyperplasia/epidemiology, gingival hyperplasia/etiology, periodontal index, renal transplantation/adverse effects
Como citar
Journal of Periodontology. Chicago: Amer Acad Periodontology, v. 74, n. 1, p. 51-56, 2003.