Publicação: A Role of Oral Bacteria in Bisphosphonate-induced Osteonecrosis of the Jaw
Carregando...
Data
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Sage Publications Inc
Tipo
Artigo
Direito de acesso
Acesso restrito
Resumo
No consensus has yet been reached to associate oral bacteria conclusively with the etio-pathogenesis of bisphosphonate-induced osteonecrosis of the jaw (BONJ). Therefore, the present study examined the effects of oral bacteria on the development of BONJ-like lesions in a mouse model. In the pamidronate (Pam)-treated mice, but not control non-drug-treated mice, tooth extraction followed by oral infection with Fusobacterium nucleatum caused BONJ-like lesions and delayed epithelial healing, both of which were completely suppressed by a broad-spectrum antibiotic cocktail. Furthermore, in both in vitro and in vivo experiments, the combination of Pam and Fusobacterium nucleatum caused the death of gingival fibroblasts (GFs) and down-regulated their production of keratinocyte growth factor (KGF), which induces epithelial cell growth and migration. Therefore, in periodontal tissues pre-exposed to bisphosphonate, bacterial infection at tooth extraction sites caused diminished KGF expression in GFs, leading to a delay in the epithelial wound-healing process that was mitigated by antibiotics.
Descrição
Palavras-chave
bisphosphonate-induced osteonecrosis of the jaw, pamidronate, gingival fibroblast, KGF, wound healing, Fusobacterium nucleatum
Idioma
Inglês
Como citar
Journal of Dental Research. Thousand Oaks: Sage Publications Inc, v. 90, n. 11, p. 1339-1345, 2011.
