Publicação: Crystallization and preliminary X-ray diffraction analysis of importin-alpha acomplexed with NLS peptidomimetics
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Elsevier B.V.
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Resumo
Importin-alpha is the nuclear import receptor that recognizes cargo proteins with nuclear localization sequences (NLSs). Tile study of NLS peptidomimetics can provide a better understanding of the requirements for the molecular recognition of cargo proteins by importin-alpha, and potentially engender a large number of applications in medicine. Importin-a was crystallized with a set of six NLS peptidomimetics, and X-ray diffraction data were collected in the range 2.1-2.5 angstrom resolution. Preliminary electron density calculations show that the ligands are present in the crystals. (c) 2005 Elsevier B.V All rights reserved.
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crystallization, X-ray crystallography, importin-alpha, karyopherin-alpha, nuclear localization sequence, NLS peptidomimetic ligand
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Inglês
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Biochimica Et Biophysica Acta-proteins and Proteomics. Amsterdam: Elsevier B.V., v. 1750, n. 1, p. 9-13, 2005.
