Deuterium Equilibrium Time in Saliva of Newborn Infants
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Data
2009-04-01
Autores
Marti Traver, Luis Angelo
Martinez, Francisco Eulogio
Ferriolli, Eduardo
Marchini, Julio Sergio
Monteiro, Jacqueline Pontes
Pfrimer, Karina
Michelin Sanchez, Ana Paula
de Oliveira, Thais
Ducatti, Carlos [UNESP]
Camelo, Jose Simon
Título da Revista
ISSN da Revista
Título de Volume
Editor
Lippincott Williams & Wilkins
Resumo
There is an increasing interest about the use of stable isotopes for body composition analysis in pediatrics. To ensure the success of total body water analysis by the deuterium dilution method, it is fundamental to determine the equilibrium tune (plateau) of deuterium in the body fluid studied.Objectives: We report here the equilibration time of deuterium oxide in the saliva of newborns after oral intake of the isotope.Methods: Twenty healthy term newborn infants, 10 males and 10 females, were analyzed. Saliva was collected from each newborn before the oral administration of a 100 mg/kg dose of deuterium oxide (baseline sample) and then at 1-hour intervals for 5 hours after administration. Deuterium enrichment of saliva was determined by isotope ratio mass spectrometry according to the recommendations of the International Atomic Energy Agency.Results: The plateau time of deuterium in saliva occurred 3 hours after oral administration of the stable isotope.Conclusion: These data are essential for further studies on the body composition of newborn infants. To the best of our knowledge, this is the first study regarding the equilibration time of deuterium in the saliva of term newborns. JPGN 48:471-474, 2009.
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Palavras-chave
Body composition, Deuterium, Newborn, Saliva, TBW
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Journal of Pediatric Gastroenterology and Nutrition. Philadelphia: Lippincott Williams & Wilkins, v. 48, n. 4, p. 471-474, 2009.