Antinociceptive and anti-inflammatory activities of ethanolic extracts of Lychnophora species
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Data
2008-02-28
Autores
Guzzo, L. S.
Saude-Guimaraes, D. A.
Silva, A. C. A.
Lombardi, J. A. [UNESP]
Guimaraes, H. N.
Grabe-Guimaraes, A.
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Editor
Elsevier B.V.
Resumo
Extracts from Lychnophora species are traditionally used in Brazil as anti-inflammatory, and to treat bruise, pain and rheumatism. The ethanolic extract of aerial parts of five species of Lychnophoras and one specie of Lychnophoriopsis were examined for the antinociceptive (hot-plate and writhing tests) and anti-inflammatory (carrageenan-induced paw oedema test) activity in mice, by oral and topical routes, respectively. In the hot-plate test, the Lychnophora pinaster (0.75 g/kg) and Lychnophora ericoides (1.50 g/kg) extracts significantly increased the time for licking of the paws. The species Lychnophora passerina, Lychnophoriopsis candelabrum and Lychnophora pinaster, using the dose of 0.75 g/kg, and Lychnophora ericoides and Lychnophora trichocarpha in both doses evaluated (0.75 and 1.50 g/kg) significantly reduced the number of writhes induced by acetic acid. The administration of Lychnophora pinaster and Lychnophora trichocarpha ointments, in both concentrations evaluated (5 and 10%, w/w), and Lychnophora passerina and Lychnophoriopsis candelabrum, in the concentration of 10%, significantly reduced the paw oedema measured 3 h after carrageenan administration, suggesting, for the first time, an anti-inflammatory activity upon topical administration of these species. The present work comparatively demonstrated the antinociceptive and anti-inflammatory activities of some Brazilian Lychnophoras. (C) 2007 Elsevier B.V. All rights reserved.
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Lychnophoras, anti-inflammatory activity, carrageenan, antinociceptive activity, hot-plate test, writhing test
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Journal of Ethnopharmacology. Clare: Elsevier B.V., v. 116, n. 1, p. 120-124, 2008.