Biochemical and structural investigations of Bothropstoxin-II, a myotoxic Asp49 phospholipase A(2) from Bothrops jararacussu venom
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Data
2008-09-01
Autores
Murakami, Mario T. [UNESP]
Lourenzoni, Marco R.
Arruda, Emerson Z.
Tomaz, Marcelo A.
Vicoti, Magno M. [UNESP]
Abrego, Jose R. B. [UNESP]
Melo, Paulo A.
Arni, Raghuvir K. [UNESP]
Título da Revista
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Editor
Bentham Science Publ Ltd
Resumo
Bothropstoxin-II a calcium-dependent enzyme from Bothrops jararacussu venom causes tissue damage and several haemostatic disorders including platelet aggregation. In order to elucidate the structural determinants of its multiple pharmacological activities, we have studied the effects of suramin on Bothropstoxin-II and present details concerning the mode of binding.
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Palavras-chave
phospholipases A(2), suramin, pharmacological activities, structural studies
Como citar
Protein and Peptide Letters. Sharjah: Bentham Science Publ Ltd, v. 15, n. 9, p. 1002-1008, 2008.