Low-Level Laser Therapy and Calcitonin in Bone Repair: Densitometric Analysis
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Data
2012-01-01
Autores
Ribeiro, Tatiana Pinto
Nascimento, Simone Bustamante
Cardoso, Claudia Alessandra
Hage, Raduan
Almeida, Janete Dias [UNESP]
Loschiavo Arisawa, Emilia Angela
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Hindawi Publishing Corporation
Resumo
The aim of this work was to evaluate the association of low-level laser therapy (LLLT, 830 nm) and calcitonin in bone repair considering that bone healing remains a challenge to health professionals. Calcitonin has antiosteoclastic action and LLLT is a treatment that uses low-level lasers or light-emitting diodes to alter cellular function. Both are used to improve bone healing. Densitometry is a clinical noninvasive valuable tool used to evaluate bone mineral density (BMD). Sixty male rats were submitted to bone defect with a trephine bur, randomly divided into four groups of 15 animals each: control (C); synthetic salmon calcitonin (Ca); LLLT (La); LLLT combined with calcitonin (LaCa). Animals from Ca and LaCa received 2UI/Kg synthetic salmon calcitonin intramuscularly on alternate days after surgery. Animals from groups La and LaCa were treated with infrared LLLT (830 nm, 10mW, 20 J/cm(2), 6 s, contact mode). Five animals from each group were euthanized 7, 14, and 21 days after surgery and bone defects were analyzed by densitometry. Statistical analysis showed a significant difference in BMD values in LaCa group at 7 and 21 days (P = 0, 005). The results of the densitometric study showed that LLLT (830 nm) combined with calcitonin improved bone repair.
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International Journal of Photoenergy. New York: Hindawi Publishing Corporation, p. 5, 2012.