Peptídeos cíclicos de biomassa vegetal: características, diversidade, biossíntese e atividades biológicas
Data
2009-01-01
Autores
Picchi, Douglas Gatte [UNESP]
Altei, Wanessa Fernanda [UNESP]
Saito, Mônica Sue [UNESP]
Bolzani, Vanderlan da Silva [UNESP]
Cilli, Eduardo Maffud [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Sociedade Brasileira de Química
Resumo
Natural peptides are outstanding as the most promising macromolecules in the search for new drugs, especially those of cyclic nature. The higher plants revealed a very peculiar composition of their cyclic peptides, which distinguish themselves by a head-to-tail cyclization. It is possible to define two groups of cyclic peptides from plant biomass. Those called in this review as Eucyclopeptides formed by 2-12 amino acid, and Cyclotides considered as circular polypeptides, composed of 29-37 amino acid that retain three disulfides bridges in an arrangement known as cyclic cystine knot. Searching for plant peptides should form into a subject for scientific research in the forefront of great importance for bioprospecting natural products macromolecular.
Descrição
Palavras-chave
cyclic peptides, eucyclopeptides, cyclotides
Como citar
Química Nova. Sociedade Brasileira de Química, v. 32, n. 5, p. 1262-1277, 2009.