Spectrophotometric Determination of Captopril Through Charge Transfer Complex Formation Using Fractional Factorial and Central Composite Design
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Data
2011-08-01
Autores
Ribeiro, Paulo R. S.
Pezza, Leonardo [UNESP]
Pezza, Helena Redigolo [UNESP]
Tognolli, Joao O. [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Colegio Farmaceuticos Provincia de Buenos Aires
Resumo
A new spectrophotometric method was developed for the determination of captopril (n donor) through charge transfer complex formation with p-chloranil (pi acceptor). The different experimental parameters that affect the absorbance intensity were carefully studied. Thus, these parameters were optimized using chemometric methods of fractional factorial and central composite design. At the optimum reaction conditions, the rectilinear calibration graphs were obtained in the concentration range 1.86 x 10(-4) to 738 x 10(-4) mol/L captopril with an excellent correlation coefficient (r = 0.9996). The proposed procedure could be applied successfully for the determination of the investigated drug in their pharmaceutical dosage forms with a good precision and accuracy compared to official and reported method as revealed by F- and t-tests at 95 % confidence level. No interference was observed from common excipients in formulations.
Descrição
Palavras-chave
Captopril, Charge transfer complex, Chemometric methods, Pharmaceuticals formulations
Como citar
Latin American Journal of Pharmacy. La Plata: Colegio Farmaceuticos Provincia de Buenos Aires, v. 30, n. 6, p. 1158-1166, 2011.