Determinação espectrofotométrica de citrato de sildenafil em formulações farmacêuticas
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Data
2008-01-01
Autores
Weinert, Patrícia Los [UNESP]
Pezza, Leonardo [UNESP]
Pezza, Helena Redigolo [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Sociedade Brasileira de Química
Resumo
This paper describes a simple and rapid spectrophotometric method for quantitative determination of sildenafil citrate based on its reaction with p-chloranil accelerated by hydrogen peroxide, producing a stable purple compound (λmax= 535 nm). In the absence of peroxide this reaction is very slow. The experimental conditions were optimized by using response surface methodologies. Beer's law is obeyed in a concentration range of 8.52 x 10-5 - 1.70 x 10-3 mol L-1 (r = 0.999). The detection limit was 1.96 x 10-5 mol L-1. The method was successfully applied for the determination of sildenafil citrate in medicines with good accuracy and precision.
Descrição
Palavras-chave
sildenafil citrate, p-chloranil, spectrophotometry
Como citar
Química Nova. Sociedade Brasileira de Química, v. 31, n. 5, p. 1112-1116, 2008.