Síndrome da apneia obstrutiva do sono e o potencial auditivo P300
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Data
2011-12-01
Autores
Martins, Carlos Henrique [UNESP]
Castro Júnior, Ney de
Costa Filho, Orozimbo Alves [UNESP]
Souza Neto, Osmar Mesquita de
Título da Revista
ISSN da Revista
Título de Volume
Editor
Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial
Resumo
A Síndrome da Apneia Obstrutiva do Sono (SAOS) diminui as capacidades da atenção, memória e concentração, fatores relacionados com a cognição. A análise dos parâmetros do P300 auditivo permitiria inferir disfunção cognitiva. OBJETIVO: Comparar os dados da polissonografia e do P300 auditivo em adultos, roncopatas primários com portadores de SAOS. CASUÍSTICA E MÉTODO: Estudo prospectivo em roncopatas primários (N=12) e em portadores de SAOS (N=54), submetidos à polissonografia definidos pelo índice de apneia e hipopneia (IAH). As variáveis da polissonografia e as do P300 foram comparadas, pelos testes T de Student, exato de Fisher, regressão logística e análise de correlação com nível de significância de 5%. RESULTADOS: O IAH apresentou correlação inversa com a oximetria em ambos os grupos. A prevalência do P300 foi menor no G.SAOS (teste exato de Fisher, p=0,027). A idade dos pacientes não influenciou a prevalência do P300 (análise de regressão; p=0,232). A amplitude do P300 foi menor do G.SAOS (teste T de Student; p=0,003) a latência do P300 foi semelhante em ambos os grupos (teste T de Student; p=0,89). CONCLUSÃO: A redução da amplitude do P300 nos portadores de SAOS sugere disfunção cognitiva induzida por diminuição da memória auditiva.
The obstructive sleep apnea syndrome (OSAS) reduces attention span, memory and concentration capacities, all associated with cognition. The analysis of the auditory P300 parameters could help infer cognitive dysfunction. OBJECTIVE: To compare the data from polysomnography and the auditory P300 in adults, primary snorers with OSAS patients. MATERIALS and METHODS: Prospective study with primary snorers (N=12) and in OSAS patients (N=54), submitted to polysomnography, defined by the apnea-hypopnea index (AHI). The polysomnography and P300 variables were compared by the t-Student test, the Exact Fisher's Test, logistic regression and analysis of correlation with a significance level of 5%. RESULTS: AIH had an inverse correlation with the oximetry in both groups. The P300 prevalence was lower in the OSAS group (Fisher's Exact Test, p=0.027). Patient age did not influence the P300 prevalence (regression analysis; p=0.232). The P300 amplitude was lower in the OSAS group (t-Student test; p=0.003) and the P300 latency was similar in both groups (t-Student test; p=0.89). CONCLUSION: The reduction in the P300 amplitude in patients with OSAS suggests cognitive dysfunction induced by a reduction in auditory memory.
The obstructive sleep apnea syndrome (OSAS) reduces attention span, memory and concentration capacities, all associated with cognition. The analysis of the auditory P300 parameters could help infer cognitive dysfunction. OBJECTIVE: To compare the data from polysomnography and the auditory P300 in adults, primary snorers with OSAS patients. MATERIALS and METHODS: Prospective study with primary snorers (N=12) and in OSAS patients (N=54), submitted to polysomnography, defined by the apnea-hypopnea index (AHI). The polysomnography and P300 variables were compared by the t-Student test, the Exact Fisher's Test, logistic regression and analysis of correlation with a significance level of 5%. RESULTS: AIH had an inverse correlation with the oximetry in both groups. The P300 prevalence was lower in the OSAS group (Fisher's Exact Test, p=0.027). Patient age did not influence the P300 prevalence (regression analysis; p=0.232). The P300 amplitude was lower in the OSAS group (t-Student test; p=0.003) and the P300 latency was similar in both groups (t-Student test; p=0.89). CONCLUSION: The reduction in the P300 amplitude in patients with OSAS suggests cognitive dysfunction induced by a reduction in auditory memory.
Descrição
Palavras-chave
apneia do sono tipo obstrutiva, cognição, potenciais evocados auditivos, potencial evocado p300, transtornos respiratórios, auditory, cognition, event related potentials, evoked potentials, p300, obstructive, espiration disorders, sleep apnea
Como citar
Brazilian Journal of Otorhinolaryngology. Associação Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial, v. 77, n. 6, p. 700-705, 2011.