Caracterização do complexo de inclusão ropivacaína: β-ciclodextrina
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Data
2007-10-01
Autores
Fraceto, Leonardo Fernandes [UNESP]
Gonçalves, Marcos Moisés
Moraes, Carolina Morales
Araújo, Daniele Ribeiro de
Zanella, Luciana
Paula, Eneida de
Pertinhez, Thelma de Aguiar
Título da Revista
ISSN da Revista
Título de Volume
Editor
Sociedade Brasileira de Química
Resumo
Characteriza of the inclusion complex ropivacaine: β-cyclodextrin. Ropivacaine (RVC) is a widely used local anesthetic. The complexation of RVC with β-cyclodextrin (β-CD) is of great interest for the development of more efficient local anesthetic formulations. The present work focuses on the characterization of the RVC:β-CD complex by nuclear magnetic resonance (NMR). The stoichiometry of the complex is 1:2 RVC:β-CD. DOSY-NMR shows that the association constant is 55.5 M-1. Longitudinal relaxation time results show that RVC changes its mobility in the presence of β-CD. This study is focused on the physicochemical characterization of inclusion complexes that are potentials options for pain treatment.
Descrição
Palavras-chave
ropivacaine, cyclodextrin, NMR
Como citar
Química Nova. Sociedade Brasileira de Química, v. 30, n. 5, p. 1203-1207, 2007.