Correlations between differences in amino-terminal sequences and different hemolytic activity of sticholysins
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Data
2007-12-15
Autores
Cilli, Eduardo Maffud [UNESP]
Pigossi, Fabio T. [UNESP]
Crusca, Edson [UNESP]
Ros, Uris
Martinez, Diana
Lanio, Maria E.
Alvarez, Carlos
Schreier, Shirley
Título da Revista
ISSN da Revista
Título de Volume
Editor
Elsevier B.V.
Resumo
Sticholysins I and II (St I and St II) are cytolysins produced by the sea anemone Stichodactyla helianthus. In spite of their 93% sequence homology, St II is more hemolytic against human erythrocytes than St 1. In order to establish the possible causes of this difference, we studied the hemolytic activity of synthetic peptides containing sequences from the N-termini of both proteins. The results demonstrated that the differences in hemolytic activity of the toxins could be ascribed at least partly to differences in their N-termini. (c) 2007 Elsevier Ltd. All rights reserved.
Descrição
Palavras-chave
sticholysin, peptides, hemolytic activity, sea anemone
Como citar
Toxicon. Oxford: Pergamon-Elsevier B.V., v. 50, n. 8, p. 1201-1204, 2007.