Voltammetric determination of fenbendazole in veterinarian formulations

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Data

2002-09-05

Autores

de Oliveira, M. F.
Stradiotto, Nelson Ramos [UNESP]

Título da Revista

ISSN da Revista

Título de Volume

Editor

Elsevier B.V.

Resumo

A versatile voltammetric method for quantitative determination of fenbendazole (FBZ) in commercial tablets has been proposed, where direct dissolution of tablets is carried out in 0.1 mol l(-1) tetrabutylamoniun tetrafluorborate containing dimethylformamide solutions. Linear sweep (LSV), square wave (SWV) and differential pulse (DPV) voltammetry techniques were applied to study FBZ at a glassy carbon electrode, exhibiting a well defined irreversible oxidation peak at 1.15 V vs. SCE. This methodology allows a precise quantitative determination of FBZ presenting detection limits of 5.2 x 10(-5) (LSV), 5.0 x 10(-6) (DPV) and 5.0 x 10(-5) mol l(-1) (SWV). (C) 2002 Elsevier B.V. B.V. All rights reserved.

Descrição

Palavras-chave

fenbendazole, anthelmintic, voltammetric determination

Como citar

Journal of Pharmaceutical and Biomedical Analysis. Oxford: Pergamon-Elsevier B.V., v. 30, n. 2, p. 279-284, 2002.