Complexos fosfínicos e suas aplicações na medicina
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Data
1996-11-01
Autores
Queiroz, S. L.
Batista, A. A.
Título da Revista
ISSN da Revista
Título de Volume
Editor
Soc Brasileira Quimica
Resumo
Phosphines are well known to chemists. The ligands themselves are widely used in organic synthesis (e.g. The Wittig reaction) and transition metal phosphine complexes have been studied extensively primarily for their applications as hydrogenation catalysts (e.g. Wilkinson's catalyst). In this article attention is focused on the biological properties of phosphines and metal phosphine complexes since the triethylphosphine Au(I) complex, auranofin, has been used as antiarthritic drug for clinical use. This fact has provided a stimulus for exploration of the biological chemistry of phosphines and their metal complexes. Metal phosphine complexes also offer potential as heart-imaging agents and anticancer drugs.
Descrição
Palavras-chave
phosphines, complexes, biological properties
Como citar
Quimica Nova. São Paulo: Soc Brasileira Quimica, v. 19, n. 6, p. 651-659, 1996.