Molecular model for the binary complex of uropepsin and pepstatin
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Academic Press Inc.
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The three-dimensional structure of human uropepsin complexed with pepstatin has been modelled using human pepsin as a template. Uropepsin is an aspartic proteinase from the urine, produced in the form of pepsinogen A in the gastric mucosa. The structure is bilobal, consisting of two predominantly beta -sheet lobes which, as observed in other aspartic proteinases, are related by a pseudo twofold axis. A structural comparison between binary complexes of pepsin:pepstatin and uropepsin:pepstatin is discussed. (C) 2001 Academic Press.
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aspartic proteinase, uropepsin, pepstatin, complex, model, Structure
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Inglês
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Biochemical and Biophysical Research Communications. San Diego: Academic Press Inc., v. 287, n. 1, p. 277-281, 2001.
