Antifungal constituents from roots of Virola surinamensis
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Elsevier B.V.
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Chromatographic fractionation of the dichloromethane extract from roots of Virola surinamensis yielded two new natural products, 3-epi-juruenolide C and 2'-hydroxy-7,4'-dimethoxyisoflavone, as well as various known steroids, lignans, isoflavones, flavonoids and diarylpropanes. of these, alpha,2'-dihydroxy-4,3'-dimethoxydihydrochal biochanin A and 2'-hydroxy-7,4'-dimethoxyisoflavone displayed antifungal activity against Cladosporium cladosporioides at a minimum amount of 5 mu g, whereas 7-hydroxyflavanone and 7-hydroxy-4'-methoxyisoflavone exhibited an antifungal activity 10-fold higher than the positive control Nystatin. (C) 1999 Elsevier B.V. Ltd. All rights reserved.
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Virola surinamensis, Myristicaceae, flavonoids, lignans, gamma-lactones, antifungal activity
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Inglês
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Phytochemistry. Oxford: Pergamon-Elsevier B.V., v. 51, n. 1, p. 29-33, 1999.
