Catecholaminergic responses in vas deferens isolated from rats submitted to acute swimming stress
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Data
1995-09-01
Autores
Chies, A. B.
Pereira, OCM
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Título de Volume
Editor
Academic Press Ltd
Resumo
The study was performed to examine the responses to catecholamines in vas deferens isolated from rats submitted to acute swimming-induced stress. It was demonstrated that acute stress induces a significant subsensitivity of rat vas deferens to norepinephrine. This subsensitivity was inhibited when the experiment was carried out in the presence of either cocaine (10(-5) M) or timolol (10(-5) M). on the other hand, the rat vas deferens sensitivity to methoxamine was significantly increased by acute swimming-induced stress. Thus, despite acute swimming stress inducing a reduction in response to norepinephrine, the alpha(1)-adrenoceptor-mediated contractile response was increased. Additionally there were increases in neuronal uptake and beta(2)-adrenoceptor activity that opposes the alpha(1)-adrenoceptor activity. Integrated, these phenomena are responsible for the rat vas deferens subsensitivity to norepinephrine which may be involved in body homeostasis in stressogenic situations. (C) 1995 the Italian Pharmacological Society
Descrição
Palavras-chave
acute stress, catecholamines, adrenoceptor, neuronal uptake
Como citar
Pharmacological Research. London: Academic Press Ltd, v. 32, n. 3, p. 123-127, 1995.