Relationship between diet and anticoagulant response to warfarin - A factor analysis
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Data
2007-04-01
Autores
Custodio das Dores, Silvia Maria
Booth, Sarah L.
Martini, Ligia Aujo
de Carvalho Gouvea, Victor Hugo
Padovani, Carlos Roberto
de Abreu Maffei, Francisco Humberto
Campana, Alvaro Oscar
Rupp de Paiva, Sergio Alberto
Título da Revista
ISSN da Revista
Título de Volume
Editor
Dr Dietrich Steinkopff Verlag
Resumo
Background Diet composition is one of the factors that may contribute to intraindividual variability in the anticoagulant response to warfarin. Aim of the study To determine the associations between food pattern and anticoagulant response to warfarin in a group of Brazilian patients with vascular disease. Methods Recent and usual food intakes were assessed in 115 patients receiving warfarin; and corresponding plasma phylloquinone (vitamin K-1), serum triglyceride concentrations, prothrombin time (PT), and International Normalized Ratio (INR) were determined. A factor analysis was used to examine the association of specific foods and biochemical variables with anticoagulant data. Results Mean age was 59 +/- 15 years. Inadequate anticoagulation, defined as values of INR 2 or 3, was found in 48% of the patients. Soybean oil and kidney beans were the primary food sources of phylloquinone intake. Factor analysis yielded four separate factors, explaining 56.4% of the total variance in the data set. The factor analysis revealed that intakes of kidney beans and soybean oil, 24-h recall of phylloquinone intake, PT and INR loaded significantly on factor 1. Triglycerides, PT, INR, plasma phylloquinone, and duration of anticoagulation therapy loaded on factor 3. Conclusion Fluctuations in phylloquinone intake, particularly from kidney beans, and plasma phylloquinone concentrations were associated with variation in measures of anticoagulation (PT and INR) in a Brazilian group of patients with vascular disease.
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Palavras-chave
phylloquinone, warfarin, oral anticoagulant response, kidney beans, diet
Como citar
European Journal of Nutrition. Darmstadt: Dr Dietrich Steinkopff Verlag, v. 46, n. 3, p. 147-154, 2007.